Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 3/2019

SORPTION CAPACITY OF A HYDROGEL BASED ON POLYHEXAMETHYLENEGUANIDINE HYDROCHLORIDE

OLEG S. OCHIROV 1*, DANIIL N. OLENNIKOV 2, MARIA N. GRIGOREVA 1, SERGEY A. STELMAKH 1, DMITRY M. MOGNONOV 1

1.Baikal Institute of Nature Management, Siberian Division, Russian Academy of Science, 6, Sakhyanova Street, Ulan-Ude 670043, Russian Federation
2.Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, 6, Sakhyanova Street, Ulan-Ude 670043, Russian Federation

Download Full Article PDF

The study was performed in order to assess the sorption capacity of a hydrogel based on polyhexamethyleneguanidine hydrochloride by using the method of doping the hydrogel with cefotaxime antibiotic from the cephalosporin series. According to the HPLC method with UV detection the sorption of antibiotic into the hydrogel was more than 50% and the percentage of drug released within 40 minutes exposure to ultrasound was 15%. The study results showed the possibility of using hydrogels based on polyhexamethyleneguanidine hydrochloride as potential drug carrier.