Romanian Society of Pharmaceutical Sciences
 

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SIMPLE AND FAST ANALYTICAL METHOD FOR THE EVALUATION OF THE ENCAPSULATION AND RELEASE PROFILE OF DOXORUBICIN FROM DRUG DELIVERY SYSTEMS

IULIA RUS 1, MIHAELA TERTIȘ 1, VIOLETA PAŞCALĂU 2, CODRUȚA PAVEL 2, BIANCA MELEAN 1, MARIA SUCIU 3,4, CRISTIAN MOLDOVAN 5, TAMARA TOPALĂ 6, CĂTĂLIN POPA 2, ROBERT SĂNDULESCU 1, CECILIA CRISTEA 1*

1Department of Analytical Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy,
400349, Cluj-Napoca, Romania
2Department of Materials Science and Engineering, Technical University of Cluj-Napoca, 400641, Cluj-Napoca, Romania
3National Institute for Research and Development of Isotopic and Molecular Technologies, 400293, Cluj-Napoca, Romania
4Biology and Geology Faculty, “Babeș-Bolyai” University, 400006, Cluj-Napoca, Romania
5MedFuture Research Center for Advanced Medicine “Iuliu Haţieganu” University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania
6Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400010, Cluj-Napoca, Romania

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Abstract Drug delivery systems are the most researched pharmaceutical formulation, representing promising tools in the treatment of cancer. Doxorubicin is an anti-tumour drug, widely used in malignant diseases, but with serious adverse effects. The aim of this study was to develop an analytical strategy for the evaluation of the encapsulation and release of this drug from delivery systems. The electrochemical oxidation process of doxorubicin has been studied using pencil graphite electrode by a fully optimized differential pulse voltammetry procedure. This electro-analytical method was successfully applied for the evaluation of the encapsulation and release profile of doxorubicin from biocompatible and biodegradable microcapsules, UV-Vis spectroscopy being applied as control method.