SIGNIFICANT DECREASING OF THE SYSTEMIC ANTIBIOTICS’ CONSUMPTION ASSOCIATED WITH ANTIMICROBIAL STEWARDSHIP INTERVENTION CONDUCTED IN INFECTIOUS DISEASES UNIVERSITY HOSPITAL FROM EASTERN EUROPE
SIMIN-AYSEL FLORESCU1, NICULAE ION NEDELCU2*, PETRE IACOB CALISTRU1, FELICIA PETRUC2, EMANOIL CEAUȘU1,2
1.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.“Dr. Victor Babeș” Infectious and Tropical Diseases Hospital, Bucharest, Romania
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A growing body of evidences is showing that antibiotic stewardship programs are clearly followed by both optimizing of and also decreasing the adverse events associated to antimicrobials use. The paper reports the effect on systemic antibiotics (AB J01) consumption of an antimicrobial stewardship intervention consisting in a prospective audit and feedback upon the antibiotics prescribed in a 500 beds university hospital. Consumption was expressed as frequency of DDD (daily defined doses) per 1000 patients per day (DDD/1000PD); the needed data were captured from the hospital pharmacy and statistic department. The antibiotics consumption was compared between the reference year (2015) and intervention year (2016). Total consumption of AB J01 decreased from 1236 DDD/1000PD in 2015 to 1193 DDD/1000PD, in other words with 43 DDD/1000PD in absolute numbers or with 3.47% in relative ones. By ATC subgroups the top ranked decline were at: (a) quinolones (J01M) (-25.7%) and (b) aminoglycoside (J01G) (-24.3%), respectively. It was demonstrated that the intervention was associated with a decrease in the general antimicrobial consumption. Presumably more consistent effect on consumption decrease of antibiotics with broad spectrum as carbapenems and/or cephalosporins might require adding of other interventions as “time out”, for instance.