Romanian Society of Pharmaceutical Sciences

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SCREENING OF HETEROCYCLIC SUBSTITUTED SYDNONES FOR POTENTIAL BIOLOGICAL ACTIVITY

NICOLETA OLGUȚA CORNELI 1, FLORIN ALBOTA 2, CRISTIANA CERASELLA DRAGOMIRESCU 1,3, MICHAELA DINA STANESCU 4*

1.“Cantacuzino” National Institute of Research, 103 Splaiul Independenței, 050096, Bucharest, Romania
2.“C. D. Nenițescu” Centre of Organic Chemistry, 202 Splaiul Independenței, 060021 Bucharest, Romania
3.“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
4.“C. D. Nenițescu” Department of Organic Chemistry, Faculty of Applied Chemistry and Material Science, POLITEHNICA University, 1-7 Polizu Street, 011061, Bucharest, Romania

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Nowadays, the emergence of bacterial resistance to antibiotics has become a major public health concern; therefore the development of new compounds overcoming the bacterial resistance is essential. Thus, this study evaluates the in vitro antimicrobial activity of some recently synthesized sydnone derivatives, on Gram-positive (Staphylococcus aureus, Bacillus subtilis), Gram-negative (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa) bacteria and fungi (Candida albicans, Aspergillus niger) and estimates the influence of sub-inhibitory concentrations of these newly synthesized compounds on the expression of some virulence factors by bacterial strains and on adhesion ability to inert substrates.