Romanian Society of Pharmaceutical Sciences
 

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RESEARCHES REGARDING THE MONITORING COMPLEMENTARY TREATMENT IN PERIODONTITIS BY USING SALIVARY 8-OHdG BIOMARKER

VICTORIA BADEA1*, CRISTINA NUCA2, CORNELIU AMARIEI3, AGRIPINA ZAHARIA4, LAURA ADRIANA BUCUR5, MIRCEA GRIGORIAN6

1Department of Microbiology,
2 Department of Preventive Dentistry,
3 Department of Oral Health and Dental Management,
4 Department of Prosthetics,
5 Department of Pharmacognosy, Ovidius University Constanta, Faculty of Pharmacy, 1 University Street, Campus, Building B, Constanta, Romania.
6 Department of Physiology, Ovidius University Constanta, Faculty of Dental Medicine, 7 Ilarie Voronca Street, Constanta, Romania.

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The aim of this study was to evaluate the efficiency of complementary methods – apitherapy, in patients with chronic periodontitis, by using salivary levels of 8-OHdG biomarker. The study group was formed of 32 patients with chronic periodontitis (superficial and deep), that were treated 6 weeks by using: conventional methods (16 patients) and by conventional methods associated with complementary methods using an ethanolic mixture of propolis and royal jelly (16 patients). The salivary level of oxidative stress produced by bacteria species involving chronic periodontitis was determined by assessing the salivary 8- hidroxy-2-deoxy guanosine (8-OHdG) before and after the treatment using an ELISA method. Patients with chronic superficial periodontitis were cured clinically, in parallel with the decrease of the salivary level of 8-OHdG for the both types of treatment studied. At the patients with chronic deep periodontitis treated by conventional methods associated with complementary methods was observed a higher regression of periodontitis, correlated with lower levels of salivary 8-OHdG, compared with the patients treated only by the conventional method. The results suggest that apitherapy can be successfully used as a complementary method in the treatment of periodontitis. The study demonstrates the existence of a high correlation between the values of salivary 8-OHdG biomarker and the status of periodontal tissue after different ways of treatment.