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PROTECTIVE EFFECT OF GARCINIA PEDUNCULATA FRUIT RIND IN ACETIC ACID INDUCED ULCERATIVE COLITIS

RAVI MUNDUGARU 1, PADMAJA UDAYKUMAR 2, SUNIL KUMAR KN 3, SHIVANADA NAYAK 4, THOMAS JACOB 5*, ALFARHAN AH 5, RAJAKRISHNAN R 5

1.Department of Pharmacology and Pharmacognosy, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi-574118. India
2 .Department of Pharmacology, Father Muller Medical College, Mangalore 575002, India
3 .Research Officer (Pharmacognosy), Siddha Central Research Institute, Central Council for Research in Siddha, Ministry of AYUSH - Govt. of India, Chennai 60010, India
4 .Graduate Studies and Research, Faculty of Medical Sciences, University of the West Indies, Trinidad and Tobago
5 .Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia

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Inflammatory bowel disease is an idiopathic, immune mediated and chronic inflammatory condition of intestine. The objective of the present study was to elucidate the protective effect of aqueous extract of fruits of Garcinia pedunculata (AEGP) in acetic acid induced ulcerative colitis in Swiss albino mice. The mice were grouped into four different categories each with six mice. The acetic acid induced colitis was assessed by measuring macroscopic damage score as well as biochemical and histological changes in colon tissue after 7 days of treatment regimen. Administration of AEGP at 400mg/kg exhibited significant effect in lowering acetic acid induced macroscopic damage score, lipid peroxidation and histopathalogical changes in colon tissue. The results suggest that the aqueous extracts of fruits of Garcinia pedunculata have ameliorating effect on experimental colitis by enhancing cytoprotective activity.