Romanian Society of Pharmaceutical Sciences

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PROBIOTIC EFFECTS ON OXIDATIVE STRESS PATHWAYS IN DIABETES

ANCA-IOANA (AMZĂR) SCĂRLĂTESCU 1, SORINA NICOLETA VOICU 2*, MARIA-TEODORA PIȚURU 3, MIRUNA-MARIA APETROAEI 1, BRUNO ȘTEFAN VELESCU 1, DENISA IOANA UDEANU 1,4, MARINA-IONELA (ILIE) NEDEA 1, ANDREEA LETIȚIA ARSENE 1,4

1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
2 Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Splaiul Independenței 91–95, 050095 Bucharest, Romania
3 Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 105 Splaiul Independentei, 050097, Bucharest, Romania
4 “Marius Nasta” Institute of Pneumology, Bucharest, Romania

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Diabetes is a complex metabolic disorder characterized by chronic hyperglycaemia and associated with significant oxidative stress, which contributes to the progressive damage of vital tissues. This study evaluates the potential benefits of probiotics in managing oxidative stress by administering them to both untreated diabetic groups and diabetic groups receiving standard antidiabetic therapy. Oxidative stress markers were assessed in the brain to explore the gut-brain axis and its connection to microbiota enrichment, while liver analysis provided insights into peripheral impact. The results revealed significant strain-specific variations in key parameters, highlighting the potential of probiotics to regulate oxidative stress and complement antidiabetic therapy.