Romanian Society of Pharmaceutical Sciences
 

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PREPARATION AND CHARACTERIZATION OF NIOSOMES CONTAINING METRONIDAZOLE

CĂTĂLINA DANIELA STAN1, GABRIELA TĂTĂRÎNGĂ2*, CARMEN GAFIŢANU3, MARIA DRĂGAN1, STERIANA BRAHA3, MARIA CRISTINA POPESCU4, GABRIELA LISĂ5, ALINA ŞTEFANACHE6

University of Medicine and Pharmacy “Gr. T. Popa” Iaşi, Faculty of Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
1 Department of Drug Industry and Pharmaceutical Biotechnology
2 Department of Organic Chemistry
3 Department of Pharmaceutical Technology
6 Department of General and Inorganic Chemistry
4 Department of Physical Chemistry of Polymers, Institute of Macromolecular Chemistry, “P. Poni” Romanian Academy, 41A Grigore Ghica Vodă Alley, 700487, Iaşi, Romania
5 Department of Physical Chemistry, Faculty of Chemical Engineering and Environmental Protection,”Gh. Asachi” Technical University, 71D Mangeron Blv., 700050, Iaşi, Romania

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In the present study the preparation and the characterization of non-ionic surfactant vesicles (NSV, niosomes) containing metronidazole are described. NSV were prepared by lipid film hydration technique using non-ionic surfactants with cholesterol at 1:2 and 1:1 ratio. At the same time NSV were characterized by melting points, by IR spectroscopy, by TG/DTG (thermogravimetry/derived thermogravimetry) and entrapment efficiency of metronidazole (metronidazole percent concentration). The maximum metronidazole entrapment was observed in the case of non-ionic surfactant/cholesterol use at 1:1 ratio.