Romanian Society of Pharmaceutical Sciences
 

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PRELIMINARY SCREENING OF BIOLOGICAL ACTIVITIES OF SOME NEW SCHIFF BASES OF ISATINS

GABRIELA TATARINGA1, CATALINA DANIELA STAN2*, ANA–MARIA ZBANCIOC1, ALEXANDRA JITAREANU1, CRISTINA TUCHILUS3

“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
1.Department of Organic Chemistry
2.Department of Drug Industry and Pharmaceutical Biotechnology
3.Department of Microbiology

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Schiff bases of isatin/substituted isatins were prepared by reacting with 4- aminoantipyrine. The chemical structures were confirmed by 1HMR, IR spectral data and elemental analysis. The synthesized compounds were tested in vitro against a number of microorganisms in order to assess their antimicrobial and antifungal activity. The synthesized compounds were screened for their antioxidant activity, ascorbic acid being used as standard. All the investigated compounds were moderately active against Gram positive bacteria and they have a significant antioxidant activity.