Romanian Society of Pharmaceutical Sciences
 

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PHYSICOCHEMICAL INVESTIGATIONS ON SOME 2-PHENETHYLBENZOYL THIOUREA DERIVATIVES

TAMARA COTELEA1, GEORGE MIHAI NIŢULESCU2*, PETUHOV OLEG3, LAURENŢIU MORUŞCIAG2

1.“Nicolae Testemiţanu” State University of Medicine and Pharmacy, Faculty of Pharmacy, 165 Stefan cel Mare si Sfint, Chisinau, Republic of Moldova
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
3.Institute of Chemistry of Academy of Sciences of Moldova, 3 Academiei, Chisinau, Republic of Moldova

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Several physicochemical methods are proposed for the analysis of some potential antituberculosis derivatives of phenetylbenzoyl thiourea. Spectrophotometric parameters were selected in order to identify the compounds using high performance liquid chromatography (HPLC) methods. The thermogravimetric method (TGA) and differential scanning calorimetry (DSC) were used to determine the thermal stability of 2-(2-phenethyl)-benzoic acid thioureides and the method's utility was demonstrated.