Romanian Society of Pharmaceutical Sciences

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PHYSICO-CHEMICAL CHARACTERIZATION OF THE ANTIOXIDANT MIXTURE RESVERATROL-FERULIC ACID FOR APPLICATIONS IN DERMATO-COSMETIC PRODUCTS

DELIA TURCOV 1#, SIMONA BARNA 1*, LENUȚA PROFIRE 2, ANDREEA TEODORA IACOB 2#,
GABRIELA LISĂ 1, ADRIAN-CĂTĂLIN PUIȚEL 1, ANCA ZBRANCA 3, DANIELA ȘUTEU 1#

1Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, “Gheorghe Asachi” Technical University from Iași, 700050, Iași, Romania
2Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania 3Faculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania

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The aim of the paper was to identify the best combination of resveratrol - ferulic acid with the purpose of increasing the antioxidant activity and maintaining the qualities of resveratrol in the management of skin disorders. Aqueous solutions of resveratrol (1%, 3% and 5% concentrations) and hydro alcoholic solution (30%) of ferulic acid were used. The following resveratrol - ferulic acid mixtures (v/v) were considered: 1:1; 1:2; 1:3 and 1:4. The antioxidant activity of the mixtures was determined and compared with that of resveratrol, and also the physico-chemical were performed by thermogravimetric analyses and UV-VIS spectrophotometry. The results underline that the mixtures of 1% and 3% resveratrol with 0.5% ferulic acid in a ratio of 1:1 and 1:2 ensure the improvement of the antioxidant activity of resveratrol.