Romanian Society of Pharmaceutical Sciences
 

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PHARMACOKINETIC EVALUATION OF A NOVEL RUTHENIUM (III)-OFLOXACIN COMPLEX, AS POTENTIAL THERAPEUTIC AGENT

BRUNO STEFAN VELESCU1, VALENTINA ANUŢA2*, VALENTINA UIVAROŞI3

1.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania
2.Department of Physical chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania
3.Department of Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania

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The aim of the study was to investigate the pharmacokinetic profile of a novel ruthenium (III)-ofloxacin complex, with the general formula [Ru(oflo)2Cl3(DMSO)] and the released ofloxacin in an animal experimental model, following a single dose of 100 mg/kg b.w., intraperitoneally administered. A HPLC method for the simultaneous quantification of the ruthenium-ofloxacin complex and ofloxacin from rat plasma was developed and validated according to the international guidelines. The method was applied in the pharmacokinetic study. The sample analyses allowed estimating both complex and released ofloxacin pharmacokinetic profile. Both complex and released ofloxacin kinetics are described by a bicompartmental model. The obtained results suggest a pharmacokinetic profile of the complex suitable for a distribution in the animal organism.