Romanian Society of Pharmaceutical Sciences
 

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OLANZAPINE AND RISPERIDONE INFLUENCE ON GESTATION AND FETAL DEVELOPMENT IN WISTAR RATS

BIANCA EUGENIA ÖSZ1, CAMIL EUGEN VARI1*, OVIDIU SIMION COTOI2, MARIUS ȘTEFAN MĂRUȘTERI3, MARIA T. DOGARU1

1.Department of Pharmacology and Clinical Pharmacy , Faculty of Pharmacy, University of Medicine and Pharmacy , Tîrgu Mureș
2.Department of Celular and Molecular Biochemistry , Faculty of Medicine, University of Medicine and Pharmacy , Tîrgu Mureș
3.Department of Medical Informatics and Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy , Tîrgu Mureș

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There is limited data about atypical antipsychotic prescription in pregnancy because due to obvious reasons of ethical issues no randomised controlled studies can be made. Sixty pregnant female rats were divided in three groups: group A or control group (n=20), those not receiving any substance, Group B (n=20) receiving olanzapine 6 mg/kg body weight and Group C (n=20) receiving 3mg/kg body weight risperidone, by oral route. When female rats reached the 21st day of gestation they were anesthetized with halothane through gas scavenging apparatus. Cesarean dissection was done, and then the macroscopic and microscopic evaluation of uterine tissues was made. The number of live or dead embryos, the number of reabsorption and other anomalies were noted. Our experimental study revealed that olanzapine and risperidone may affect gestation in various developmental stages. The results were confirmed also by the histopatological and statistical analysis of data.