Romanian Society of Pharmaceutical Sciences
 

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NEW THIAZOLIDINE-4-ONES OF FERULIC ACID WITH ANTIOXIDANT POTENTIAL

MARIA WOLSZLEGER (DRĂGAN)1, CĂTĂLINA DANIELA STAN1, ANDREEA PÂNZARIU2, ALEXANDRA JITĂREANU3, LENUŢA PROFIRE2*

Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700115, Iaşi, România
1 .Department of Drug Industry and Pharmaceutical Biotechnology,
2 .Department of Pharmaceutical Chemistry,
3 .Department of Organic Chemistry

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New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was proved by infrared (IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. The in vitro antioxidant potential of the synthesized compounds was evaluated according to the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azinobis-(3- ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays. Some of synthesized compounds showed a good antioxidant activity which supports the favourable influence of the structural modulation on the antioxidant effects of the ferulic acid.