Romanian Society of Pharmaceutical Sciences

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NEW THIAZOLIDINE-4-ONES OF FERULIC ACID WITH ANTIOXIDANT POTENTIAL

MARIA WOLSZLEGER (DRĂGAN)1, CĂTĂLINA DANIELA STAN1, ANDREEA PÂNZARIU2, ALEXANDRA JITĂREANU3, LENUŢA PROFIRE2*

Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700115, Iaşi, România
1.Department of Drug Industry and Pharmaceutical Biotechnology,
2.Department of Pharmaceutical Chemistry,
3.Department of Organic Chemistry

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New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was proved by infrared (IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. The in vitro antioxidant potential of the synthesized compounds was evaluated according to the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azinobis-(3- ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays. Some of synthesized compounds showed a good antioxidant activity which supports the favourable influence of the structural modulation on the antioxidant effects of the ferulic acid.