Romanian Society of Pharmaceutical Sciences
 

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NEW ACYLATED DERIVATIVES OF 2-METHYL-4- OXO-QUINAZOLIN-3(4H)-IL-ACETOHYDROXAMIC ACID

MIHAELA BRATU1, DIANA CAMELIA NUȚĂ1*, MIRON TEODOR CĂPROIU2, ALEXANDRU VASILE MISSIR1, CARMEN LIMBAN1, ILEANA CORNELIA CHIRIȚĂ1, LAURENȚIU MORUȘCIAG1

1.University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2.The Organic Chemistry Center of Romanian Academy “C. D. Neniţescu”, Splaiul Independenţei 202B, Bucharest, Romania

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In our research of bioactive molecules we synthesized some new substances with 4(3H)-quinazolinone structure that may have similar pharmacological properties to those of other compounds with similar structures. These compounds are acylated derivatives of 2- methyl-4-oxo-quinazolin-3(4H)-il-acetohydroxamic acid. Their chemical structures were confirmed by elemental analysis, infrared (IR) and nuclear magnetic resonance (NMR) spectra.