Romanian Society of Pharmaceutical Sciences

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MUCOADHESIVE FILMS BASED ON POLYVINYL ALCOHOL AND BIOACTIVE COMPOUNDS FOR ORAL ADMINISTRATION: STRUCTURAL CHARACTERIZATION AND MUCOADHESIVE PROPERTIES

OANA MIHAELA NEAGU 1, LAURA GRAȚIELA VICAȘ 2*, ANA-MARIA VLASE 3, LAURIAN VLASE 4, ANNAMARIA PALLAG 2, ALIN TEUȘDEA 5, ILDIKÓ BÁCSKAY 6, ELEONORA MARIAN 2, MARIANA EUGENIA MUREȘAN 7, TÜNDE JURCA 1,2

1Doctoral School of Biomedical Science, University of Oradea, 1 University Street, 410087, Oradea, Romania 2Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st December Square, 410073, Oradea, Romania
3Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
4Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
5Faculty of Environmental Protection, University of Oradea, 26 General Magheru Avenue, 410087, Oradea, Romania
6Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 98 Nagyerdei Körút, 4032 Debrecen, Hungary
7Department of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st December Square, 410073, Oradea, Romania

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In this study, two well known plant species, Matricaria chamomilla L. and Viola tricolor L., were characterized in terms of their polyphenolic and antioxidant profiles. 1:1, 1:2 and 2:1 mixtures ratioswere obtained from the alcoholic extracts. The plant extracts were analysed by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) and by Folin- Ciocâlteu, CUPRAC and DPPH methods. Comparing the values of the bioactive principles contained in each mixture, as well as the antioxidant character, the mixture Matricariae flos/Violae tricolor flos 2:1, with an inhibition percentage of 84.28 ± 1.36%, was chosen to be incorporated into a mucoadhesive polymeric film. The formulated polymeric films were realized by incorporating 5% and 8% polyvinyl alcohol, 5% and 10% plant extract, respectively. The mucoadhesive films pH ranged between the normal salivary pH values (6.899 ± 0.016 and 7.045 ± 0.017), high folding strength and high tensile strength. According to the performed analyses and the plant extract yield operation from the polymer films, the films incorporating 5% polymer and 10% plant extract, respectively 5% polymer and 5% extract exhibited excelent results.