Romanian Society of Pharmaceutical Sciences
 

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MODELING OF THE COMPOSITION OF A SEMISOLID PROPOLIS PREPARATION, AND EVALUATION OF ITS QUALITY

KRISTINA RAMANAUSKIENĖ1, ASTA MARIJA INKĖNIENĖ1*, DAIVA LESKAUSKAITĖ2

1Lithuanian University of Health Sciences, Medicine Academy, Pharmacy Faculty, Department of Pharmaceutical Technology and Social Pharmacy. A. Mickevičiaus St. 9, LT – 44307 Kaunas, Lithuania
2Kaunas University of Technology, Department of Food Technology. Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania

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The aim of the study was to select the optimal composition of semisolid using natural materials, and to evaluate the quality of such preparation. Investigation of rheological properties, evaluation of sensory characteristics, detection and identification of phenolic acids using high-performance liquid chromatography (HPLC) were performed. The results of the rheological investigations and the study of sensory properties were evaluated, and the optimal composition of the ointment was selected: olive oil, beeswax, cocoa butter, cholesterol, soft propolis extract, and substances that improved the sensory characteristics. The base of the ointment ensures the stability of the semisolid when the active component is soft propolis extract. The results of the quantitative study by highperformance liquid chromatography identified phenolic acids and determined their amounts and showed that the predominant phenolic acids in the propolis ointment were ferulic acid and coumaric acid. The modeled hydrophobic semisolid is a stable homogenous system with positive sensory characteristics.