Romanian Society of Pharmaceutical Sciences
 

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MICROWAVE ASSISTED SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SOME NOVEL SCHIFF BASES OF CARPROFEN HYDRAZIDE

ALEXANDRA TEODORA BORDEI (TELEHOIU) 1#, DIANA CAMELIA NUȚĂ 1#, GABRIELA CORNELIA MUŞAT 2*, ALEXANDRU VASILE MISSIR 1, MIRON TEODOR CĂPROIU 2, FLOREA DUMITRAŞCU 2, IRINA ZARAFU 3, PETRE IONIȚĂ 3, CARMELLINA DANIELA BĂDICEANU 1, CARMEN LIMBAN 1, EMMA ADRIANA OZON 5

1.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest, 020956, Romania
2.Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3.“Costin D. Nenițescu” Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenței Street, Bucharest, 060023, Romania
4.Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Boulevard, Bucharest, 030018, Romania
5.Department of Pharmaceutical Technology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest, 020956, Romania

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A new series of Schiff bases was synthesised by the treatment of (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide (carprofen hydrazide) with few benzaldehyde derivatives under microwave irradiation. The IR, 1H NMR and 13C NMR spectroscopic characterization of newly synthesised compounds is reported. The Schiff bases were tested for antibacterial activity, the strongest effect being against S. aureus.