Romanian Society of Pharmaceutical Sciences

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LOW MOLECULAR WEIGHT HEPARIN IN THE PROTECTION OF PARATHYROID FUNCTION AFTER THYROID SURGERY

YOUSONG ZENG 1,2, MENGYUAN WANG 3*

1 Jinzhou Medical University Postgraduate Education Base (Chongqing University Three Gorges Hospital), Wanzhou, 404199, Chongqing, China
2 The Thirteenth People's Hospital of Chongqing, Department of General Surgery, Jiulongpo, 400053, Chongqing, China
3 Chongqing University Three Gorges Hospital, Department of Breast, Wanzhou, 404199, Chongqing, China

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Permanent hypoparathyroidism is a severe complication of thyroid surgery, affecting postoperative quality of life. This study investigated the protective effects of low molecular weight heparin (LMWH) on parathyroid function in 92 patients undergoing total thyroidectomy (June 2019-June 2023). Patients were divided into a control group (CG) receiving standard care and an experimental group (EG) receiving prophylactic calcium LMWH. LMWH (4000 AXaIU enoxaparin) was administered subcutaneously before and after surgery. Coagulation markers, parathyroid indicators and inflammatory markers were assessed pre- and post-operatively. EG showed improved coagulation function and reduced postoperative inflammation (lower IL-6 and CRP levels) compared to CG. Although both groups experienced transient reductions in parathyroid function, recovery was comparable by day 180, with no permanent hypoparathyroidism observed. LMWH improved postoperative outcomes by mitigating hypercoagulability, reducing inflammation and supporting parathyroid function, suggesting its potential benefit in thyroid surgery.