Romanian Society of Pharmaceutical Sciences
 

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IRON DEFICIENCY AND IRON-DEFICIENCY ANAEMIA IN PREGNANT WOMEN CORRECTED BY ORAL BOVINE LACTOFERRIN ADMINISTRATION

CLAUDIA MEHEDINTU1,2, OANA MARIA IONESCU2, SORIN IONESCU2, MONICA MIHAELA CIRSTOIU1,3, MIHAI CRISTIAN DUMITRASCU1,3, ELVIRA BRATILA1,4*, RUXANDRA DUMITRESCU1,5, DANIELA NUTI OPRESCU1,6, CĂLIN PETRU TĂTARU7, SIMONA VLADAREANU1,8

1.Department of Obstetrics and Gynaecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 .Department of Obstetrics and Gynaecology, “Nicolae Malaxa” Clinical Hospital, Bucharest, Romania
3 .Department of Obstetrics and Gynaecology, Emergency Clinical Hospital, Bucharest, Romania
4 .Department of Obstetrics and Gynaecology, “Saint Pantelimon” Emergency Clinical Hospital, Bucharest, Romania
5 .Department of Obstetrics and Gynaecology, “Dr. I. Cantacuzino” Clinical Hospital, Bucharest, Romania
6 .Department of Obstetrics and Gynaecology, “Polizu” Obstetrics-Gynaecology Hospital - “Alfred Rusescu” IOMC, Bucharest, Romania
7 .Department of Ophthalmological Emergencies, Clinical Hospital of Ophthalmology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
8 .Department of Neonatology, “Elias” Emergency University Hospital, Bucharest, Romania

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Iron deficiency and iron – deficiency anaemia represent factors which increase maternal, foetal and neonatal mortality and morbidity. In pregnancy, the failure of oral iron-based therapy in restoring the biological parameters made it necessary to pursue other solutions. Due to its iron-binding properties, bovine lactoferrin has been used in preventing and treating iron – deficiency anaemia in pregnancy. In our study, 406 patients of different ages, parities and gestational ages received oral therapy with bovine lactoferrin, 100 mg twice a day. After 90 days, more than 90% of patients that completed the study had a positive response. These considerations, as well as positive neonatal results, support the claim that the use of bovine lactoferrin re-balances iron levels in pregnant women with iron deficiency and iron-deficiency anaemia.