Romanian Society of Pharmaceutical Sciences
 

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IRON DEFICIENCY AND IRON-DEFICIENCY ANAEMIA IN PREGNANT WOMEN CORRECTED BY ORAL BOVINE LACTOFERRIN ADMINISTRATION

CLAUDIA MEHEDINTU1,2, OANA MARIA IONESCU2, SORIN IONESCU2, MONICA MIHAELA CIRSTOIU1,3, MIHAI CRISTIAN DUMITRASCU1,3, ELVIRA BRATILA1,4*, RUXANDRA DUMITRESCU1,5, DANIELA NUTI OPRESCU1,6, CĂLIN PETRU TĂTARU7, SIMONA VLADAREANU1,8

1.Department of Obstetrics and Gynaecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.Department of Obstetrics and Gynaecology, “Nicolae Malaxa” Clinical Hospital, Bucharest, Romania
3.Department of Obstetrics and Gynaecology, Emergency Clinical Hospital, Bucharest, Romania
4.Department of Obstetrics and Gynaecology, “Saint Pantelimon” Emergency Clinical Hospital, Bucharest, Romania
5.Department of Obstetrics and Gynaecology, “Dr. I. Cantacuzino” Clinical Hospital, Bucharest, Romania
6.Department of Obstetrics and Gynaecology, “Polizu” Obstetrics-Gynaecology Hospital - “Alfred Rusescu” IOMC, Bucharest, Romania
7.Department of Ophthalmological Emergencies, Clinical Hospital of Ophthalmology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
8.Department of Neonatology, “Elias” Emergency University Hospital, Bucharest, Romania

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Iron deficiency and iron – deficiency anaemia represent factors which increase maternal, foetal and neonatal mortality and morbidity. In pregnancy, the failure of oral iron-based therapy in restoring the biological parameters made it necessary to pursue other solutions. Due to its iron-binding properties, bovine lactoferrin has been used in preventing and treating iron – deficiency anaemia in pregnancy. In our study, 406 patients of different ages, parities and gestational ages received oral therapy with bovine lactoferrin, 100 mg twice a day. After 90 days, more than 90% of patients that completed the study had a positive response. These considerations, as well as positive neonatal results, support the claim that the use of bovine lactoferrin re-balances iron levels in pregnant women with iron deficiency and iron-deficiency anaemia.