Romanian Society of Pharmaceutical Sciences
 

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INTRODUCING VEGETABLE OILS IN A PREPARATION OF KETOCONAZOLE LIPOSOMES USING A THIN-FILM HYDRATION METHOD

OLGA POPOVSKA 1*, ZORAN KAVRAKOVSKI 2, VESNA RAFAJLOVSKA 1

1.Ss. Cyril and Methodius University in Skopje, Faculty of Technology and Metallurgy, Rudjer Boskovic 16, 1000 Skopje, Republic of Macedonia
2.Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000 Skopje, Republic of Macedonia

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Multilamellar ketoconazole liposome vesicles (MLV) were prepared using a thin-film hydration method. Sunflower and olive oil were introduced as solvents in a preparation of ketoconazole liposomes. The liposomes were evaluated by determination of morphological characteristics, encapsulation efficiency of ketoconazole and ζ-potential. The highest encapsulation efficiency was found to be 91.21% in the ratio of ketoconazole, cholesterol, and L-α-phosphatidylcholine 3.33:1:3.33 w/w/w.