Romanian Society of Pharmaceutical Sciences
 

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INTRODUCING VEGETABLE OILS IN A PREPARATION OF KETOCONAZOLE LIPOSOMES USING A THIN-FILM HYDRATION METHOD

OLGA POPOVSKA 1*, ZORAN KAVRAKOVSKI 2, VESNA RAFAJLOVSKA 1

1.Ss. Cyril and Methodius University in Skopje, Faculty of Technology and Metallurgy, Rudjer Boskovic 16, 1000 Skopje, Republic of Macedonia
2 .Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000 Skopje, Republic of Macedonia

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Multilamellar ketoconazole liposome vesicles (MLV) were prepared using a thin-film hydration method. Sunflower and olive oil were introduced as solvents in a preparation of ketoconazole liposomes. The liposomes were evaluated by determination of morphological characteristics, encapsulation efficiency of ketoconazole and ζ-potential. The highest encapsulation efficiency was found to be 91.21% in the ratio of ketoconazole, cholesterol, and L-α-phosphatidylcholine 3.33:1:3.33 w/w/w.