Romanian Society of Pharmaceutical Sciences
 

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INCORPORATION OF NEW BENZIMIDAZOLE COMPOUNDS INTO LIPID NANOSTRUCTURES IN ORDER TO OBTAIN PHOTOPROTECTIVE FORMULATIONS

IRINEL GRAȚIELA MĂNESCU1, GABRIELA BADEA2*, LUCIAN ISCRULESCU1, MIRCEA IOVU1, TEODORA BALACI1

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania
2 .Polytechnic University of Bucharest, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania

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The exposure to UVA and UVB radiation is responsible for damaging the skin’s natural defence, having mechanism various adverse effects, from sunburns to skin cancer. The skin application of cosmetic products that possess photo protective activity raises some concerns associated with the toxicity of the synthetic organic UV filters used on market today. Thus, it is necessary to develop new photo protective products based on safe to use UV filters. The objective of study was to encapsulate several non-toxic benzimidazole derivatives, which absorb in the UVA and UVB domains, into lipid nanostructures in order to improve their photo protective action. The developed lipid nanostructures were embedded into topical cosmetic emulsions and the obtained preparations were evaluated in vitro for their sun protection factor (SPF).