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IN VITRO EVALUATION OF 5-FLUOROURACIL DISSOLUTION PROFILES FROM VAGINAL BIOADHESIVE TABLETS

LAURA PALADE, IULIANA POPOVICI, ILEANA COJOCARU^*

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The paper assesses the dissolution profiles for twelve original formula of vaginal bioadhesive tablets containing 100mg of 5-fluorouracil (5-FU)/tablet. For the quantitative determination of 5-FU from the vaginal bioadhesive tablets, as well as for its in vitro release using the dissolution test, a high performance liquid chromatography (HPLC) method was used; the method was elaborated and validated. The results of the research pointed out that P1, P4, P5, P6 formulations, consisting of acrylic acid derivatives with various reticular degrees, in the first three hours released 80-99% of the total 5-FU, while the formulations including cellulose derivatives of various viscosity degrees, P7-12 released the substance slower, reaching the concentration level of 35-60% in 6 hours and 60-80% in 10 hours.