Romanian Society of Pharmaceutical Sciences
 

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IN VITRO ESTROGENIC/ANTI-ESTROGENIC EFFECTS OF CERTAIN FOOD ADDITIVES AND COSMETIC PRESERVATIVES

ANCA POP1, BELA KISS1*, TUDOR DRUGAN2, JULIEN CHERFAN1, FELICIA LOGHIN1

1.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Toxicology, Cluj-Napoca, Romania
2.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Informatics and Biostatistics, Cluj-Napoca, Romania

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In the present study we evaluated the estrogenic/anti-estrogenic effects of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) and butyl paraben (BP), compounds extensively used as antioxidants/conservatives in food, food packaging, cosmetics and pharmaceuticals, using the luciferase assay. BP and PG were found out to have dual effect. BHA was discovered to have only anti-estrogenic effects, while BHT was the only compound tested in the present studies that did not have any effect.