Romanian Society of Pharmaceutical Sciences

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IN VITRO ANTIPROLIFERATIVE ACTIVITY OF FLAVONOLS: FISETIN, QUERCETIN AND KAEMPFEROL AND THEIR CYCLODEXTRIN COMPLEXES

CORINA DANCIU1, COSMIN CITU2, ISTVAN ZUPKO3, ROXANA GHIULAI4*, PETRU MATUSZ5, IOANA ZINUCA PAVEL1, ALEXANDRA POPESCU6, IULIA PINZARU7, GEORGETA SIMU6, VLAD C. DALIBORCA8

1.Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
2.Department XII, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
3.Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eotvos u. 6, Szeged H-6720, Hungary
4.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
5.Department of Anatomy and Embryology, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
6.Department of Physical Chemistry, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
7.Department of Toxicology, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
8.Department of Biochemistry and Pharmacology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timişoara, România

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The aim of this study was to evaluate the in vitro antiproliferative capacity of the flavonols: fisetin, quercetin and kaempferol alone and incorporated in β-cyclodextrins, on A2780 (human ovarian carcinoma cells), MDA-MB-231 (human breast cancer cells) and SiHa (human cervix cancer cells). On the selected cell lines, among the tested compounds, fisetin was the most active in terms of antiproliferative activity. The most sensitive cell line to the tested flavonols was found to be the human ovarian carcinoma A2780 cell line. The inclusion complexes between the selected flavonols with ramified β-cyclodextrins determined different effects, depending on the cell line and on the tested compound.