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GHRELIN AS MARKER OF AGE ASSOCIATED CARDIO-VASCULAR DISEASE

CLAUDIA BĂCANU, DENISA MARGINĂ^*, NICULINA MITREA, NOORA WAEL RASHEED

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Studies regarding the pathology associated with obesity are abundant in literature, but there is no clear opinion regarding the relationship between the cardiovascular risk and the age of patients. Several studies are nowadays devoted to finding the parameters that would allow a precise evaluation of the health status of ageing patients. Cardio-vascular diseases (CVD) represent the main co-morbidity of the ageing process. The aim of the present study was the assessment of ghrelin dynamics in serum samples obtained from patients with different age, with or without cardio-vascular diseases. Our results show a negative association between the age of the selected patients and the ghrelin level in blood samples. Also, the cardio-vascular patients were characterized by a lower level of ghrelin compared to healthy subjects. Results lead to the conclusion that ghrelin is a reliable marker for the cardio-vascular risk and that ghrelin modulation should be considered as a novel therapeutic strategy.