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FORMULATION OF ORODISPERSIBLE TABLETS CONTAINING MELOXICAM AND THEIR IN VITRO AND IN VIVO CHARACTERIZATION

SONIA IURIAN^1*, IOAN TOMUȚĂ¹, SORIN E. LEUCUȚA¹

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The aim of this experimental work was to evaluate the influence of formulation variables on the characteristics of orodispersible tablets, using a statistical method, in order to reach a balance between their properties: fast disintegration, convenient hardness and good palatability. 26 formulations were obtained, according to a D-Optimal experimental design. The formulation factors were the disintegrate ratio, compression force, sweeteners ratio and diluents ratio. For the response variables, the tablets were characterized in vitro and in vivo. The obtained results showed that the two most important factors were the diluents ratio and the compression force. Choosing well balanced formulation factors and technological variables enables the obtaining of tablets with convenient mechanical strength, water absorption capacity, oral disintegration time, in vitro dissolution time and palatability. The conditions for the obtaining of the highest crushing strength, shortest disintegration time and best palatability were generated. Taking into account the results for the chosen variables’ influence, an optimal formulation was obtained.