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FORMULATION OF BIOADHESIVE HYDROPHILIC MATRIX TABLETS WITH FAMOTIDINE USING DIFFERENT COMBINATIONS OF POLYMERS

ADELA E. PEREANU^*, IOAN TOMUŢA, SORIN E. LEUCUŢA

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The aim of this work was to prepare bioadhesive matrix tablets with famotidine (FAMO) using different polymer and filler combinations in order to determine the best combination regarding the water uptake properties, the drug release profile and the bioadhesive properties. The employed bioadhesive polymers were: hydroxypropylmethylcellulose (HPMC), polyacrylic acid (Carbopol, CP) 71G, acrylic acid polymer crosslinked with divinyl glycol (Polycarbophil, PC) and sodium carboxymethylcellulose (SCMC). The employed fillers where: isomaltose (ISO) and dicalcium phosphate (DCP). For this purpose an experimental design with 5 variables and 3 levels was used. The tablets were analyzed regarding the in vitro water uptake properties, the drug release behavior and the bioadhesive properties. From the obtained results it was concluded that the formulations containing three bioadhesive polymers in the highest used concentration (HPMC, CP/PC and SCMC) have advantages in comparison to the formulations with two or just one bioadhesive polymer in regard to water uptake and dissolution profiles. The bioadhesive properties of the tablets were positively influenced by the combination of CP and SCMC in the same formulation.