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FORMULATION AND PREPARATION OF OMEPRAZOL AND KETOPROFEN BI-LAYER TABLETS BY DIRECT COMPRESSION METHOD

CARMEN ANATOLIA GAFITANU, MONICA ILIUTA STAMATE^*, ILEANA CORNELIA COJOCARU

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The aim of the study was to prepare and characterize bi-layer tablets containing ketoprofen and omeprazole in order to reduce the side effects of ketoprofen and to improve the therapeutic benefits and patients’ compliance to treatment. Bi-layer tablets of ketoprofen 100 mg and 20 mg omeprazole (in form of enteric pellets) were prepared by direct compression technique using carbopol, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, Kollidon® as matrix-forming agents. These polymers have the ability to hydrate in digestive fluids and form a gel on the surface of the tablets undergoing erosion processes in time, in order to control the release of active drugs from compressed matrix tablets. Hardness, friability and release studies were performed on bi-layer tablets. The results have shown the influence of polymers over the physicochemical properties and the release profile of the active drugs.