Romanian Society of Pharmaceutical Sciences
 

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FORMULATION AND IN VITRO RELEASE TESTING OF RECTAL SUPPOSITORIES CONTAINING NIMESULIDE

ANCA CECILIA NICOARĂ1, RADU GEORGE CAZACINCU2*, DUMITRU LUPULEASA1, DALIA SIMONA MIRON3, FLAVIAN ȘTEFAN RĂDULESCU4

1.University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 6 Traian Vuia street, 020956, Bucharest, Romania
2.Ovidius University, Faculty of Pharmacy, 1 Aleea Universitatii, Constanta, Romania
3.University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics and Informatics. 6 Traian Vuia street,020956, Bucharest, Romania
4.University of Medicine and Pharmacy Carol Davila Bucharest, Faculty of Pharmacy, Department of Drug Industry and Pharmaceutical Biotechnologies, 6 Traian Vuia street, 020956, Bucharest, Romania

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cteristics. The experimental protocol implemented for the evaluation of the pharmaceutical quality and in vitro performance included determinations of softening and disintegration times, as well as the release assessment using a dissolution equipment with compendial 40 mesh and Palmeri baskets. The mean profiles displayed a very low dissolution of the lipophilic drug, with release rates influenced on the melting and spreading pattern. The release kinetics was adequately described by the Higuchi model.