Romanian Society of Pharmaceutical Sciences
 

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FORMULATION AND ANTIOXIDANT INVESTIGATION OF CREAMS CONTAINING ROBINIAE PSEUDACACIAE FLOS L. ETHANOLIC EXTRACT

TÜNDE JURCA 1, ANNAMARIA PALLAG 1, LAURA VICAȘ 1*, ELEONORA MARIAN 1, MARIANA MUREȘAN 1, ZOLTÁN UJHELYI 2,3, PÁLMA FEHÉR 2,3, ILDIKÓ BÁCSKAY 2,3,4

1University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, 29 Nicolae Jiga Street, 410028, Oradea, Romania
2University of Debrecen, Faculty of Pharmacy, Department of Pharmaceutical Technology, Nagyerdei krt 98, 4032 Debrecen, Hungary
3Doctoral School of Pharmaceutical Sciences, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
4Institute of Healthcare Industry, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary

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Some vegetable products can be incorporated into skin care products in order to treat conditions such as skin dryness and can function as an antioxidant. Creams were formulated with Robiniae pseudacaciae flos extracts. This study was aimed to investigate the antioxidant activity of the ethanolic extracts and the obtained creams. The fractions of Robiniae pseudacaciae flos were found to be rich sources of polyphenols with marked antioxidant activity, evidenced by the DPPH method. The phenolic acids, identified by HPLC-RP with UV detection, were gallic acid, sinapic acid, caffeic acid and vanillic acid and the predominant flavonoids were quercetin, rutin and luteolin. The extract was previously dissolved in Transcutol and then mixed in the same oil/water (O/W) base containing Sucrose ester SP50, Tefose® 63, Sedefos™ 75 as emulsifiers. The in vitro release of different compounds was evaluated by the Franz diffusion method. The creams containing Robiniae pseudacaciae flos extract exhibited large amounts of diffused substances. Antioxidant activity was determined by the DPPH (1,1-diphenyl2-pycrylhydrazyl) method, according to the methodology described by Brand-Williams.