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EXPERIMENTAL PHARMACOLOGICAL RESEARCHES REGARDING THE INFLUENCE OF SODIUM FLUORIDE IN ALLOPATHIC AND HOMEOPATHIC DOSES ON CENTRAL NERVOUS SYSTEM’S PERFORMANCES. A CORRELATION BETWEEN BEHAVIORAL RESPONSE IN CLASSIC MAZE TEST AND MORPHOLOGICAL ASPECTS OF CEREBRAL CORTEX

VIOLETTA BĂRAN-POESINA¹, SIMONA NEGREŞ^2*, DUMITRU DOBRESCU², NICOLETA DIMCEVICI-POESINA², ANDREEA DIMCEVICI-POESINA³, ADRIAN FEGHIU⁴, THEODOR SOARE⁴, MANUELLA MILITARU⁴

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The influence of fluorine administration on central nervous system’s (CNS) performances in female mice treated during gestation with two distinct doses of sodium fluoride (NaF): 0.25 mg and 0.50 mg. The research extended also to offspring (generation 1 – F1), treated with NaF in allopathic (0.25 and 0.50 mg), homeopathic (7CH) or with the association between the two types (allopathic and homeopathic) of doses. CNS performance modification was also assessed in the second generation offspring (F2), in which fluorine was exclusively taken from ascendant generations. Evaluation of CNS activity was performed by determining clearing time in classic maze (CM) at several time intervals (roughly 21 days between determinations). Experimental results showed that, in young offspring (1 – F1) from ascendants treated with the same substance, CNS performances in investigative capacity are influenced depending on dose, gender and age. Similar effect was recorded for homeopathic remedy 7CH for which the influence on CNS performance is strongly correlated to the stage of physical development of offspring and to doses of NaF administered to ascendants. The results of pharmacological tests correlate strongly to modifications noted during anatomical pathology examination of cerebral cortex.