Romanian Society of Pharmaceutical Sciences
 

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EXPERIMENTAL INVESTIGATIONS ON THE EFFECTS OF BIDENS TRIPARTITA EXTRACTS IN NOCICEPTIVE REACTIVITY

RAOUL VASILE LUPUŞORU1, LILIANA MITITELU-TARŢĂU2*, RAUL BOGDAN SANDU2, GRAŢIELA POPA3, MARIN ZAGNAT4, CĂTĂLINA ELENA LUPUŞORU2

“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, code 700115, Iasi, Romania
1 .Faculty of Medicine, Department of Patho-Physiology
2 .Faculty of Medicine, Department of Pharmacology-Algesiology
3 .Faculty of Pharmacy, Department of Pharmaceutical Technology
4 .Faculty of Medical Bioengineering, Department of Bioengineering Sciences

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Bidens tripartita (B. tripartita), a flowering plant belonging to the Bidens genus, Compositae family, Asteroideae subfamily, has been widely used in traditional medicine for its antiseptic, anti-inflammatory, antioxidant, astringent, diuretic, febrifuge, narcotic and sedative effects. The present study investigated the effects of two B. tripartita extracts in somatic nociceptive reactivity in rats. The experiment was carried out on 4 groups of 6 Wistar rats each, treated intraperitoneally for 1 month with: group I (control): 0.5 mL/100g body weight saline solution; group II (BT-alcoholic): 200 mg/kg b.w. B. tripartita alcoholic extract; group III (BT-aqueous): 250 mg/kg b.w. B. tripartita aqueous extract, group IV (KET): 10 mg/kg b.w. ketoprofen. The nociceptive cutaneous testing was performed using the tail flick assay, to determine the latency time response to tail thermal noxious stimulation. The chronic use of BT-alcoholic, but not of BT-aqueous produced a statistically significant increase of the latency time response (p < 0.05), compared to control in the tail flick test. Its effects were less intense than those of KET. The administration of BT-alcoholic extract showed analgesic effects in tail flick test in rats.