Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF THE IMPACT INDUCED BY THE ENVIRONMENTAL EXPOSURE TO A MIXTURE OF ORGANIC SOLVENTS ON SKH1 MICE

DORINA ELENA CORICOVAC1, CRISTINA ADRIANA DEHELEAN1*, LILIANA CSEH2, CODRUȚA MARINELA ȘOICA1, ANGELA BOGLUT1, GEORGETA-MARIA SIMU1

1“Victor Babeș” University of Medicine and Pharmacy, Faculty of Pharmacy, 2 Eftimie Murgu Square, RO-300041, Timișoara, Romania
2Institute of Chemistry of the Romanian Academy, 24 Mihai Viteazul Boulevard, RO-300223, Timișoara, Romania

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The present study aimed to evaluate the local and systemic acute effects associated with the environmental exposure to a mixture of aromatic organic compounds resulting from the COSORB process. The experiment was performed on SKH1 hairless male mice according to the following experimental design: exposure for 30 minutes/day/5 days to the organic mixture. To assess the potential toxicity, were verified several parameters: mice weight, skin physiological parameters using a non-invasive method and the muscular strength by the means of the inverted screen test. The test group of mice (the mice exposed to organic mixture) exhibited weight loss, changes in the skin parameters values and muscular weakness. Altogether, our results showed that the environmental exposure to the organic mixture was associated with noxious effects both at skin and systemic levels.