Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF THE ANTI-INFLAMMATORY POTENTIAL OF SOME POLYHETEROCYCLIC COMPOUNDS WITH THIAZOLE RING IN ACUTE INFLAMMATION MODELS. PART II. CELLULAR RESPONSE

ALINA ELENA PÂRVU2, CRISTINA MOGOŞAN1*, OLIVIU VOŞTINARU1, CRISTINA POP1, VALENTIN ZAHARIA3

1Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy, University of Medicine and Pharmacy“Iuliu Haţieganu”, RO-400012,Cluj-Napoca, Romania
2 Department of Physiopathology, Faculty of Medicine, University of Medicine and Pharmacy“Iuliu Haţieganu”, RO-400012,Cluj-Napoca, Romania
3 Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy“Iuliu Haţieganu”, RO-400012,Cluj-Napoca, Romania

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The cellular anti-inflammatory effect of some polyheterocyclic compounds with thiazole ring was evaluated in an acute experimental inflammation model. The compounds had an anti-inflammatory effect as they decreased the white cells count, the percentage of neutrophils and the phagocyte index.