Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF PROTECTIVE EFFECTS OF QUERCETIN AND VANADYL SULPHATE IN ALLOXAN INDUCED DIABETES MODEL

BRUNO ŞTEFAN VELESCU 1#, VALENTINA ANUŢA 2#*, ANTON ALDEA 3#, MARIANA JINGA 4,7#, PAVEL CĂLIN COBELESCHI 5#, CRISTINA ELENA ZBÂRCEA 1#, VALENTINA UIVAROSI 6#

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 6 Traian Vuia Str., 020956, Bucharest, Romania
2 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Physical and Colloidal Chemistry, 6 Traian Vuia Str., 020956, Bucharest, Romania
3 .BLD Pharma SRL, 96A Intrarea Sulfinei, 077125, Măgurele, Jud Ilfov, Romania
4 .”Dr. Carol Davila” Central Military Emergency Hospital, Internal Medicine and Gastroenterology Clinic, 88 Mircea Vulcănescu St., 10816, Bucharest, Romania
5 .Transilvania University, Faculty of Medicine, Department of Internal Medicine, 56th Nicolae Bălcescu St., Brașov, Romania
6 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Inorganic Chemistry, 6 Traian Vuia Str., 020956, Bucharest, Romania
7 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Eroilor Sanitari Blvd, Bucharest.

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Various vanadium compounds demonstrated decreasing blood sugar levels in different diabetes animal models, and are considered to be promising antidiabetic agents. Oxovanadium(IV) complexes with flavonoid ligands, with beneficial effects in diabetic pathology, like the complex di-µ-hydroxobis(quercetinatooxovanadium)(IV), proved to decrease the elevated blood sugar levels and the total cholesterol, without impact on the insulin levels in alloxan induced diabetic rats. The aim of the study was to evaluate the effect of quercetin and vanadyl sulphate on rats exposed to alloxan, as diabetogenic agent. The rats’ treatment consisted in daily oral administered doses of 0.01 mmol/kg b.w. of vanadyl sulphate, 0.02 mmol/kg b.w. of quercetin and respectively 0.01/0.02 mmol/kg b.w. of vanadyl sulphate - quercetin mixture, over a 4 weeks period. The experimental results pointed out protective effects of quercetin and vanadyl sulphate in alloxan exposed rats on the induced diabetic onset, rats’ glycaemia and impaired lipid metabolism.