Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF ANTIBACTERIAL ACTIVITY OF TWO POLY-(CARBOXYBETAINES) DERIVED FROM POLY(4-VINYLPYRIDINE)

ANCA GIORGIANA GRIGORAŞ1*, SIMONA ISABELA DUNCA2, LĂCRĂMIOARA OCHIUZ3

1.“Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487, Iași, Romania
2.“Alexandru Ioan Cuza” University of Iași, Faculty of Biology, 20A Carol I Boulevard, 700505, Iași, Romania
3.“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universității Street, 700115, Iași, Romania

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Polybetaines have been still intensively studied due to their biomedical potential. In this work, two poly(carboxybetaines) derived from poly(4-vinylpyridine) P4VP that have methylene (P4VPB-1) or ethylene (P4VPB-2) spacer between N+ and COO- groups were preliminary investigated by viscometry in salted aqueous solutions in order to correlate the “anti-polyelectrolyte” behaviour and conformational state of these polymers with their antibacterial potential. The microbiological tests revealed that P4VPB-1 did not interfere with the metabolism of Escherichia coli ATCC 25922 or Staphylococcus aureus ATCC 25923. Also, P4VPB-2 inhibited only the growth and multiplication of S. aureus and recorded a minimum inhibitory concentration (MIC) of 6.4 mg/mL.