Romanian Society of Pharmaceutical Sciences
 

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EQUESTRIAN SYNOVIAL FLUID MESENCHYMAL STEM CELLS, A POTENTIAL EXPERIMENTAL MODEL FOR OSTEOARTICULAR THERAPIES

CRISTIAN MIHĂIȚĂ CRECAN 1#, SIMONA LUMINIȚA OPREAN 2*, MIRELA ALEXANDRA TRIPON 3, ANDREI BODNARIUC 4, LUCIANA RUS 5, EMOKE PALL 3#, DANIELA CLAUDIA OROS 6, IANCU MORAR 3#

1.University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Surgical Techniques, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
2.“Iuliu Hațieganu”, University of Medicine and Pharmacy, Faculty of Pharmacy, Department of General and Inorganic Chemistry, Cluj-Napoca, Romania
3.University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Reproduction and Obstetrics, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
4.University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Pathophysiology, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
5.University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Department of Parasitology, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania
6.Private Practitioner, Cluj-Napoca, Romania

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Mesenchymal stem cells (MSCs) therapy has become widely used to treat degenerative diseases. There are various tissue specific sources of stem cells with different therapeutic applications, therefore it is necessary to further investigate the characteristics and differences between MSCs from different origins, their potential and limitations. Osteoarthritis is the most common joint disease affecting both human and horses, and current treatment options have strong limitations. The use of MSCs to treat degenerative osteo-articular diseases has proven to be effective but further studies are needed to establish the safest and most effective protocol with regard to source, allogenic versus autologous cells and dose. Horses can be used as a large animal model for in vivo testing, due to some joint structural similarities. In the current study we compared the characteristics of synovial fluid-derived mesenchymal stem cells (SF-MSCs) harvested from horses with different joints degenerative diseases, to those observed in injured human joints. The results of this study showed that SF-MSCs from injured horse joints have substantial chondrogenic potential and they show great similarities to those observed in humans.