Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 3/2025

EMERGING APPLICATIONS OF BOTULINUM NEUROTOXIN TYPE A (BoNTA) IN SKIN REJUVENATION AND FACIAL CONTOURING

EUGEN GABRIEL TURCU 1,2,3, DANIELA-ELENA POPA 2*, DIANA-MIHAELA CIUC 4

1 “Bagdasar-Arseni” Clinical Emergency Hospital, Plastic Surgery Department, 12 Berceni Road, 041915, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
3 “Zone Medical Estet”, Plastic Aesthetic Surgery Clinic, 7 Cap. Petre Costescu Street, 042079, Bucharest, Romania
4 CF 2 Clinical Hospital, ENT Department, 63 Mărăști Boulevard, 011464, Bucharest, Romania

Download Full Article PDF

Often identified as Botox, botulinum toxin (BoNTA) is a neurotoxin produced by the bacteria Clostridium botulinum. From treating muscular spasms and chronic migraines to reducing dynamic wrinkles, this toxin has found wide application in both medical and cosmetic areas. The following research explores the chemistry of botulinum toxin, its mechanism of action, and indications for face rejuvenation. This retrospective study analysed the safety profile, efficacy, and patient satisfaction correlated with BoNTA treatments for cosmetic needs within a cohort of 965 patients observed between 2019 and 2023. The majority of the treatment sites included the glabella, forehead, crow's feet, and other off-label areas. There were primary recorded patient demographics, therapeutic concentrations, adverse reactions, and follow-up data. While tracking adverse reactions, safety was evaluated, and efficacy was determined based on physician assessment and patient-reported results. As BoNTA is a safe and efficient cosmetic procedure with few adverse reactions and excellent patient satisfaction, the results confirm BoNTA's reliability as a consistent option with a great safety profile for face rejuvenation. Its ability to generate evident, natural-looking results with little downtime makes it essential for anyone seeking an attractive, fresh look. When used alone or in combination with other treatments, BoNTA provides an individualised approach for accomplishing various cosmetic goals of patients.