« Back to Farmacia Journal 6/2013

ELECTROCHEMICAL AND SPECTRAL STUDY OF CYCLODEXTRINS INTERACTIONS WITH SOME PHARMACEUTICAL SUBSTANCES

LUMINIŢA FRITEA, MIHAELA TERTIŞ, TAMARA LIANA TOPALĂ, ROBERT SĂNDULESCU^*

Download Full Article PDF

The influence of cyclodextrins on the electrochemical response of some pharmaceutical molecules has been investigated on carbon paste electrode (CPE) using cyclic voltammetry (CV) and square wave voltammetry (SWV). The oxidation peak of the analytes is shifted to internal positive potential values and the current intensity is decreased, modifications which can be explained by the formation of inclusion complexes. FTIR studies were used to confirm the complexation. Carbon paste electrodes modified with β- cyclodextrin (CPE/ β-CD) showed an enhanced electrochemical response of ascorbic and uric acid in comparison with the unmodified carbon paste electrode.