EFFICACY OF SUBGINGIVAL MINOCYCLINE HYDROCHLORIDE COMBINED WITH TEA POLYPHENOLS IN THE TREATMENT OF PERI-IMPLANTITIS AND CHANGES IN THE GINGIVAL CREVICULAR FLUID MICROBIOTA STRUCTURE
WEI MENG, MINYI ZHANG, YAN XIE, XING GUO, ZUOXIAN CHEN, MEILU ZHOU, LIFEN YIN, TAOHUA PAN *
Department of Periodontics, Changsha Stomatological Hospital, Changsha 410008, Hunan, China
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This retrospective study evaluated the efficacy of combining minocycline hydrochloride with tea polyphenols in treating peri-implantitis and its effects on gingival crevicular fluid (GCF) microbiota in 119 patients (January 2023–December 2024). A control group (n = 53) received subgingival minocycline alone, while an experimental group (n = 66) received minocycline plus tea polyphenols. Both groups showed significant improvements in periodontal parameters (PLI, SBI, AL, PD) and inflammatory markers (MMP-8, sICAM-1, PGE2, IL-17F, IL-1β) (p < 0.05), with greater improvements in the experimental group. Microbiota composition changed minimally in the control group, whereas the experimental group showed significant reductions in Porphyromonas gingivalis and Fusobacterium nucleatum, increases in Streptococcus oralis and S. mutans, and stable Lactobacillus levels. The experimental group achieved a higher overall effectiveness rate and fewer ineffective cases (p < 0.05). Adverse reactions, including dizziness, nausea and gingival injury, were also significantly lower (p < 0.05). This combination therapy improved clinical and inflammatory outcomes and beneficially modulated GCF microbiota, demonstrating good safety and tolerability in peri-implantitis treatment.
