Romanian Society of Pharmaceutical Sciences
 

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EFFICACY OF ANTIBIOTIC APPROACHES IN NEWBORNS AND INFANTS WITH NASOLACRIMAL DUCT OBSTRUCTION

ROXANA CALMUSCHI (TRINC) 1,2#, FLORIN ADRIAN SZASZ 3#, SORIN TRINC 2*, SILVIA ROBU 4#, DANA TUTUNARU 4, IONELA DANIELA MORARIU 5#, AFILON JOMPAN 1

1.“Vasile Goldiș” Western University of Arad, Faculty of Medicine, Arad, Romania
2.Arad County Clinical Hospital, Department of Ophtalmology, Arad, Romania
3.University of Medicine and Pharmacy Oradea, Department of Obstetrics-Gynecology, Oradea, Romania
4.“Dunărea de Jos” University, Faculty of Medicine and Pharmacy, Galați, Romania
5.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Iaşi, Romania

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The maximal incidence of nasolacrimal duct obstruction (NLDO) is in new-borns and infants due to the minimal development and anatomy of the nasolacrimal duct, to the declive predominant position and to the inefficient local cleaning. We analysed the paraclinical investigations and treatment modalities in patients from Ophthalmology department in Arad County Clinical Hospital (Arad CCH) between 2016 and 2017. Most of the NLDO patients developed cultures of positive lacrimal secretions, with or without clinical signs, of which the most common Gram(+) germ (68%) was Staphylococcus aureus (50%) while the most common Gram(–) germ was Haemophilus influenzae (8.63%) of the total number of patients. These results are similar to the average quoted in the specialized literature. According to antibiogram, the Gram(+) germs were most susceptible to Netilmycin and Levofloxacin and Gram(–) germs were the most susceptible to Ciprofloxacin. All patients with visible symptoms of superinfection of the lacrimal ducts developed positive cultures, while only 33.73% of those with epiphora showed bacterial growth in conjunctival secretions. It demonstrated the inefficiency of antibiotic treatment in 66.27% of patients with simple epiphora without first having a specialized ophthalmological examination with analysis of conjunctival secretions. Self-medication in those cases leads to alteration of lacrimal film composition and uncontrolled resistance to antibiotics.