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EFFECTS OF DIFFERENT DOSES OF NITROGLYCERIN COMBINED WITH ATENOLOL ON PLASMA VISCOSITY AND INFLAMMATORY RESPONSE IN PATIENTS WITH ANGINA PECTORIS

NA LIANG ¹, SUYUN ZHOU ²*

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In order to analyse the clinical efficacy and safety of high-dose nitroglycerin combined with atenolol in patients with angina pectoris, 120 patients were randomly divided into an experimental group (n = 60) and a control group (n = 60). The patients in the experimental group received high-dose nitroglycerin (0.5 mg nitroglycerin, three times a day, for 30 consecutive days) plus atenolol (6.25 mg twice a day) while the patients in the control group received low-dose nitroglycerin (0.2 mg nitroglycerin, three times a day, for 30 consecutive days) + atenolol (6.25 mg twice a day). The results showed that the left ventricular enddiastolic diameter (LVEDD), left ventricular end-systolic volume (LVESV) and left ventricular ejection fraction (LVEF) in the experimental group were significantly lower than those in the control group. The levels of TNF-α, IL-6 and plasma viscosity in the experimental group were significantly lower than those in the control group. The overall clinical response rate of the experimental group (90%) was significantly higher than that of the control group (71.67%). The incidence of adverse reactions in the experimental group (8.33%) was not significantly different from that in the control group (10%), indicating that high-dose nitroglycerin combined with atenolol could effectively reduce the serum inflammatory factor level and plasma viscosity in patients with angina pectoris compared with low-dose nitroglycerin, and the therapeutic effect on patients was more significant, without increasing adverse drug reactions, with high clinical safety