Romanian Society of Pharmaceutical Sciences

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EFFECTS OF CHRYSIN ON HAEMATOLOGICAL PARAMETERS IN RATS

MARIA HALINA BORAWSKA1*, RENATA MARKIEWICZ-ŻUKOWSKA1, DIANA SAWICKA2, SYLWIA KATARZYNA NALIWAJKO1, KATARZYNA SOCHA1, WIOLETA OMELJANIUK1, HALINA CAR3

1.Department of Bromatology, Medical University of Białystok, Poland
2.Center of Experimental Medicine, Medical University of Białystok, Poland
3.Department of Experimental Pharmacology, Medical University of Białystok, Poland

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Chrysin (5,7-dihydroxyflavone) is a natural flavonoid found in plant extracts, which has significant biological and pharmacological properties. In this study, we tested the influence of chrysin on haematological parameters in the blood of rats treated with various doses of chrysin (25, 50, 100 mg/kg bw) for one or 7 days. Total red blood cell (RBC), haemoglobin (HGB), and haematocrit (HTC) values decreased markedly in rats exposed for one day to 25 mg/kg bw (p<0.01), 50 mg/kg bw (p<0.05), and 100 mg/kg bw (p <0.01) of chrysin. There was an increase in RBC, HGB, and HTC values in rats after administration of 100 mg/kg bw of chrysin once a day over a 7-day period as well as in RBC and HTC values in rats exposed to 25 and 50 mg/kg bw of chrysin over the same period of time. The average corpuscular haemoglobin concentration (MCHC) value decreased significantly when rats were exposed to chrysin once, at a dose of 50 mg/kg bw, or for 7 days, a doses of 25 or 50 mg/kg bw. After 7 days of chrysin administration the body weight of rats increased visibly. Chrysin may significantly influence haematological parameters and the differences between a single and multiple administrations have strong clinical implications. According to the results of our study, chrysin given more than once may beneficially influence haematological parameters and increase body weight in rats. It opens new perspectives for the use of such a flavonoid in anaemia.