Romanian Society of Pharmaceutical Sciences

« Back to Farmacia Journal 6/2024

EFFECTS OF CANNABIS SATIVA L. SEED OIL ON PRO-INFLAMMATORY CYTOKINES AND LIVER AND KIDNEY FUNCTIONS IN OBESE FEMALE WISTAR RATS: A RANDOMIZED CONTROLLED TRIAL

HADIL S. SUBIH 1*, TASNEEM S. ABU GHAZAL 1, BELAL S. OBEIDAT 2, LINDA ALYAHYA 3

1 Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan
2 Department of Animal Production, Faculty of Agriculture, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan
3 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia

Download Full Article PDF

Obesity is a global health concern linked to chronic diseases, including kidney and liver dysfunction. Functional foods with health benefits beyond basic nutrition are gaining attention as potential interventions. This study investigates the effects of hemp seed oil (HSO) on kidney and liver function and pro-inflammatory cytokines (IL-2, IL-6, TNF-α) in obese rats. Female Wistar rats (n = 84) were divided into four groups, fed a high-fat or control diet for 15 weeks, with subgroups receiving 10% HSO supplementation. At weeks 5, 10 and 15, 7 rats per group were euthanized, and blood samples were analysed. A high-fat diet increased inflammation and impaired kidney and liver function, while HSO supplementation improved levels of AST, ALT, uric acid, IL-2 and IL-6. These findings suggest HSO may counteract obesity-induced inflammation and organ dysfunction. Further research is needed to explore its therapeutic potential.