Romanian Society of Pharmaceutical Sciences
 

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EFFECTS OF A TOPICAL PREPARATION CONTAINING SAMBUCI FOLIUM EXTRACT IN EXPERIMENTAL MODEL OF THERMAL SKIN BURNS ON RATS

GEORGE DAN MOGOŞANU1*, FLORINA CARMEN POPESCU2, CRISTINA JANA BUSUIOC2, OLTIN TIBERIU POP2, LAURENȚIU MOGOANTĂ2, HORIA PÂRVĂNESCU3, GABRIELA RĂU4, IOAN LASCĂR5

1.Department of Pharmacognosy and Phytotherapy
2.Research Centre for Microscopic Morphology and Immunology
3.Department of Plastic Surgery and Reconstructive Microsurgery
4.Department of Organic Chemistry, Medicinal Chemistry University of Medicine and Pharmacy of Craiova, 2–4 Petru Rareş Street, 200349 Craiova, Romania
5.Department of Plastic Surgery and Reconstructive Microsurgery, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Sector 1, 020022 Bucharest, Romania

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The astringent, anti-inflammatory, antiseptic and cicatrizing effect of a coldcream containing Sambuci folium soft extract was established in experimental model of thermal skin burns, in Wistar rats. Animals in the first group, treated with cold-cream containing 10% vegetal extract, had a favourable evolution, the wound healing being almost complete after 21 days. The reference group, treated with 1% silver sulfadiazine cream, and the control group, treated with cold-cream base, showed a delay of wound healing, the epithelisation after 21 days being incomplete.