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EFFECT OF RHIZOMA SMILACIS GLABRAE EXTRACT IN IMPROVEMENT OF SKIN LESIONS AND INFLAMMATION IN MICE WITH PSORIASIS AND HYPERURICEMIA

FANG YAO ¹, HONGSHENG DING ¹, BIN DU ¹, JING MA ¹, MENGZHU JIN ²*

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This study investigated the mechanisms by which Rhizoma Smilacis Glabrae extract (RSGE) alleviates psoriasis associated with hyperuricemia (HUA) in a murine model. Fifty male mice were allocated to five groups: control, IMQ-induced psoriasis, HUA, HUA + IMQ, and HUA + IMQ treated with RSGE. Clinical severity (PASI score), serum biochemical parameters, histopathological changes, inflammatory cytokine expression, and MAPK signaling pathway activation were evaluated. IMQ- induced psoriasis increased PASI scores, lesion thickness, epidermal hyperplasia, inflammatory cytokine expression (IL-6, IL- 17, IL-23, TNF-α), and MAPK pathway activation. HUA elevated serum uric acid (UA), creatinine (Cr), and blood urea nitro- gen (BUN) levels. Coexistence of psoriasis and HUA further aggravated both cutaneous lesions and systemic biochemical abnormalities, accompanied by enhanced inflammatory responses and MAPK signaling activation (p < 0.05). Treatment with RSGE significantly reduced PASI scores, improved histopathological alterations, decreased UA, Cr, and BUN levels, and suppressed inflammatory cytokine expression and MAPK pathway activation compared with the HUA + IMQ group. These findings suggest that RSGE effectively attenuates psoriasis complicated by hyperuricemia, likely through modulation of in- flammatory responses and inhibition of the MAPK signaling pathway.