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EFFECT OF NOREPINEPHRINE ON HEMODYNAMICS OF SYSTEMIC CIRCULATION AND OXYGEN METABOLISM IN EMERGENCY SEPTIC SHOCK

YUN HU 1, YINGLIN WANG 2, QINGYE LI 2*

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The aim of this study was to analyse the value of using norepinephrine (NE) and dopamine (DA) in the clinical management of patients with emergency septic shock (SS). Eighty adult patients with SS who were treated in the hospital were included as research subjects. These patients were randomly divided into an experimental (Expt) group (NE) and a control (Ctrl) group (DA), with 40 cases per group. The hemodynamic parameters and renal function indicators of the two groups were compared. Mean arterial pressure (MAP) 1 hour and 6 hours after drug administration was significantly higher in the Expt group than after fluid resuscitation (FR). Heart rate (HR) 1 hour after drug administration was significantly lower than in the Ctrl group (p < 0.05). The blood lactic acid clearance rate (LCR) and peripheral vascular resistance index (PVRI) of the Expt group were significantly higher than those of the Ctrl group 1 h and 6 h after medication (p < 0.05). The creatinine clearance rate (CCr) and urine output (UO) of the Expt group 1 h and 6 h after liquid medication were higher than those of the Ctrl group (p < 0.05). Compared with DA, NE could effectively maintain hemodynamic stability, reduce blood lactic acid levels and improve renal function in patients with SS.