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DESIGN AND FORMULATION OF BUCCAL MUCOADHESIVE PREPARATION BASED ON SORBITAN MONOSTEARATE OLEOGEL

ELENA DINTE^*, IOAN TOMUŢĂ, RAREŞ I. IOVANOV, SORIN E. LEUCUŢA

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Eleven formulations of buccal mucoadhesive preparations based on sorbitan monostearate (SMS) oleogel in which were incorporated bioadhesive polymers, Carbopol 940 or HPMC K100M, in concentrations established according to a composite central experimental design were prepared. The drug substances, metronidazole (MZ) and ibuprofen (IB) were incorporated in a concentration of 1%. The rheological characteristics, adhesion and in vitro release of MZ and IB were studied. The analyse of the kinetic release showed a good correlation with Peppas model. A formulation containing SMS 6.87% and HPMC K100M 14.99% was identified for maximising consistency, mucoadhesivity and ensuring an in vitro prolonged drug release profile for 8 hours. The optimized formulation was characterized in terms of adhesivity, rheology and release kinetics and their reproducibility was confirmed. The optimized formulation can be considered a good candidate for application in the postextractional socket at patients presenting the risk for osteomielitis on the background of osteonecrosis.