Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 6/2017

DESIGN AND EVALUATION OF A TRANSDERMAL PATCH WITH ATORVASTATIN

PABLO SERRANO CASTAÑEDA 1,2, JOSÉ JUAN ESCOBAR-CHÁVEZ 1*, ABRAHAM TORRES AGUADO 1, ISABEL MARLEN RODRÍGUEZ CRUZ 3, LUZ MARÍA MELGOZA CONTRERAS 2

1.School of Advanced Studies Cuautitlan – National Autonomous University of Mexico, Multidisciplinary Research Unit, Laboratory 12: Transdermal Systems, Cuautitlan Teoloyucan road, km 2.5 San Sebastian Xhala C.P 54714 Cuautitlan Izcalli, State of Mexico, Mexico
2 .Autonomous Metropolitan University – Xochimilco – Department of Biological Systems, Calzada del Hueso 1100. Colonia Villa Quietud. C.P. 04960. Mexico City
3 .Regional Hospital of High Specialty of Zumpango. Teaching and Research Unit. Zumpango, State of Mexico. Zumpango-Jilotzingo Highway #400, Barrio de Santiago 2nd Section, Zumpango, State of Mexico, C.P. 55600

Download Full Article PDF

A transdermal patch loaded with atorvastatin was developed in order to improve dyslipidaemia therapy and had good drug release for several days. This transdermal system can be used as a new alternative for the treatment of hypercholesterolemia. Transdermal patches (TP) were generated by the plate casting technique; the evaluated patches were generated using a factorial design to obtain the optimum formulation. The patches were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), bioadhesion, post-wetting-bioadhesion, tensile strength, drug release studies and in vitro percutaneous absorption studies. The results obtained for optimal TP formulation showed good properties such as no interactions between drug and excipients in DSC studies, 1063.05 gf of bioadhesion and 995.9 gf for post-wetting-bioadhesion, the tensile strength of 1307.5 gf, thickness of 0.43 mm, the SEM studies showed a porous matrix with no precipitates of the drug, good drug release adjusted to Higuchi model and a flux of atorvastatin of 8.6 µg/cm2/h for percutaneous in vitro absorption. The optimal TP proved the release of atorvastatin during several days.